Targeted first-line therapy for *H. pylori* using genotypic resistance testing significantly improved eradication rates (77% to 93%) and reduced clarithromycin (36% to 22%) and levofloxacin (39% to 32%) resistance over time. Pharmacist-led interventions further boosted success. Personalized treatment was shown to improve outcomes and help curb rising antibiotic resistance.

At 24 weeks, P-CABs showed superior remission rates in erosive esophagitis (EE) versus PPIs (OR = 2.301; *p* = 0.009), especially in severe cases (LA grade C/D: OR = 2.526; *p* = 0.001). Even in mild cases (A/B), P-CABs outperformed PPIs (OR = 1.442; *p* = 0.034). Overall, P-CABs offer more effective long-term healing in EE.

A large-scale study from two national cohorts revealed that alcohol's impact on liver-related events varied by consumption and genetic predisposition. Moderate and heavy drinkers had an 18-23% risk, while mild drinking showed no effect. Those with high genetic risk and heavy alcohol consumption faced a 6.5-fold greater risk (HR 6.50), highlighting the need for tailored risk assessment.

A study utilizing NHANES data and Mendelian randomization confirmed a causal association between magnesium deficiency and obstructive sleep apnea (OSA). Individuals with higher magnesium depletion scores faced up to 64% higher odds of OSA. Genetic analysis showed magnesium reduced OSA risk, while reverse analysis found no effect of OSA on magnesium levels, highlighting the protective role of magnesium against OSA.

Children with Kawasaki disease (KD) had a modestly higher prevalence of allergic disorders than those without KD, especially rhinitis (OR 1.17) and urticaria (OR 1.19), a Korean study found. KD also increased the risk of developing these conditions, with no link to asthma or atopic dermatitis. The risk was lower when KD was diagnosed after five. Gender and urban residence contributed to allergic disease prevalence.

Higher serum 25-hydroxyvitamin D concentrations (≥50 nmol/L) in psoriasis patients significantly lowered overall mortality and cardiovascular disease by 46% and 22%, respectively, versus those with the lowest levels (<25 nmol/L), according to a recent study. Patients with adequate vitamin D showed no additional mortality or CVD risk compared to controls, highlighting vitamin D’s protective role in psoriasis.