Efficacy, Safety, and Tolerability of Isoniazid Preventive Therapy for TB in PLWHIV


This systematic review and meta-analysis identified a significant reduction in the incidence of active TB, but not all-cause mortality, among PLHIV who received IPT compared to the control. Lesser number of outcomes may be the reason for non-significant results in terms of safety outcomes of IPT. Therefore, there is a need for extensive and long-term studies to address these issues further, especially in TB/HIV endemic areas.