ACTIPEEL Gel (Lactic acid 82%)

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Chemical peeling is the most popular cosmetic procedure, used since time immemorial.  In this procedure, a chemical agent is applied to the skin to cause controlled destruction of the skin layers, followed by tissue remodelling. Chemical peels are a powerful tool to treat various skin diseases and aesthetic disorders.

Based upon how deeply a peel penetrates the skin, peels are classified as follows: superficial (epidermis), medium (up to the papillary dermis), and deep peels (mid-reticular dermis). The peel depth is influenced by factors such as the type of chemical used, peel concentration, mode of application, skin type and condition or the time allowed for the peel to be in contact with the skin.

ACTIPEEL Gel contains lactic acid 82%. It is available in a bottle of 60 ml.

Composition

Lactic acid 82%, Dimethylaminoethanol 11%, Ethoxydiglycol 2%, Xanthan gum 0.350%, Extract Phyllanthus emblica 0.001%, Extract Chamomilla recutita 0.001%, Extract Boswellia serrata gum 0.001%, Water q.s. 100%

Pharmacology

Lactic acid (pKa-3.86) is an AHA popularly used for dry and sensitive skin.1,2 Lactic acid accelerates removal of dead skin cells (corneocytes), improves skin regeneration and, thus, leads to a healthier, softer and a more radiant skin.1 It promotes ceramide (the skin lipids) synthesis and improves the skin barrier function3. It also increases the natural hyaluronic acid content in the skin, thus improving skin moisture.1 Lactic acid may work on pigmentary lesions by accelerating the turnover of the epidermis.4

The depth of skin penetration produced by AHAs is time- and concentration-dependent. So, peel depth may increase with concentration as well as time.

Dimethylaminoethanol is an analogue of the B vitamin, choline, and a precursor of acetylcholine.  It has reported to increase in skin firmness with possible improvement in the underlying facial muscle tone.5

Extract Phyllanthus emblica inhibits the enzyme, tyrosinase, promoting skin lightening. It also increases collagen production and reduces *MMP-1.6

Extract Chamomilla recutita is effective in speeding up epithelialization and wound healing of the skin.7

Extract Boswellia serrata gum contains boswelic acids, which exhibit anti-inflammatory effects.8

*MMP-1: Matrix metalloproteinase-1, an enzyme responsible for degradation of collagen

Indications

Skin rejuvenation: skin moisturizing, glow and lightening

Directions for Use

  • Clean and remove the makeup with degreasing lotion.
  • Protect the areas around the eyes, mouth and nose using petroleum jelly.
  • Using a cotton bud/gauze/brush, apply the peel quickly (approx. 20–30 seconds) to the affected area/face.9
  • Treat areas in the following order: forehead, right cheek, nose, left cheek and chin.9
  • If needed, treat the perioral, upper and lower eyelids at last.9
  • Apply feathering strokes at the edges to blend with the surrounding skin and prevent demarcation lines.9
  • Remove the peel with water after 5–10 minutes.
  • Apply a broad-spectrum sunscreen.

Caution

  • A transient stinging sensation and slight flushing of the skin are normal. Remove the peel immediately with plenty of water if hotspots or erythema appears. To avoid contact with eyes, nostrils and mouth, elevate head up to 45°. If contact occurs, rinse with water.9 Never leave the room before completing the procedure.
  • Patch testing may be advised for patients with a history of allergy or skin sensitivity.
  • Chemical peeling with ACTIPEEL Gel is contraindicated in patients with active viral, bacterial, fungal infections, unrealistic patient expectations, on photosensitizing drugs or patients who have undergone resurfacing procedures or any cutaneous surgeries (in the area to be treated) in the last 6–12 months.9

Presentation

60 ml Gel

References

  1. Step by Step: Chemical Peels. JP Medical Ltd; 2014. 147-148 p
  2. Procedures in Cosmetic Dermatology Series: Chemical Peels. Elsevier Health Sciences; 2010.9 p.
  3. Handbook of Cosmetic Science and Technology, Third Edition. CRC Press; 2009. 112 p
  4. Exp Dermatol. 2003;12 Suppl 2:43-50
  5. Am J Clin Dermatol. 2005;6(1):39-47.
  6. An Bras Dermatol. 2010 Sep-Oct;85(5):613-20.
  7. Mol Med Report. 2010 Nov 1; 3(6): 895–901.
  8. Indian J Pharm Sci. 2011 May;73(3):255-61.
  9. Indian J Dermatol Venereol Leprol. 2008 Jan 1; 74(7): S5-11

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